CKDdb-logoCKDdb - Molecule ID A0802

geneAKAP12, AKAP250
nameA-kinase anchor protein 12
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AKA12_HUMANQ02952ENSG000001310169590Hs.371240604698

Functions and classifications

GOC:cell cortex, C:cytoplasm, C:cytoskeleton, C:plasma membrane, F:protein kinase A binding, P:G-protein coupled receptor signaling pathway, P:positive regulation of cAMP biosynthetic process, P:positive regulation of protein kinase A signaling, P:protein targeting, P:regulation of protein kinase C signaling, P:signal transduction, P:positive regulation of protein kinase A signaling cascade
UniProtAlternative splicing, Complete proteome, Cytoplasm, Cytoskeleton, Lipoprotein, Myristate, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.420.0064355RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.220.00197RNA microarray19698090
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)4< 0.05LC-MS/MS20940332
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.43< 0.05RNA microarray21752957
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)4.320.0065572RNA microarray23935909
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)3.520.0000019RNA microarray24569379
Exp24761003aRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.52< 0.05LC-MS/MS24761003
Exp24761003cRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.8< 0.05LC-MS/MS24761003
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.250.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium