CKDdb-logoCKDdb - Molecule ID A0798

geneAKAP6, AKAP100
nameA-kinase anchor protein 6
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:calcium channel complex, C:caveola, C:intercalated disc, C:junctional sarcoplasmic reticulum membrane, C:nuclear envelope, C:nuclear membrane, C:perinuclear region of cytoplasm, C:T-tubule, F:adenylate cyclase binding, F:protein anchor, F:protein complex scaffold, F:protein kinase A regulatory subunit binding, P:cAMP-mediated signaling, P:cellular response to cAMP, P:cellular response to cytokine stimulus, P:negative regulation of cAMP biosynthetic process, P:positive regulation of calcineurin-NFAT signaling cascade, P:positive regulation of cell growth involved in cardiac muscle cell development, P:positive regulation of delayed rectifier potassium channel activity, P:positive regulation of NFAT protein import into nucleus, P:positive regulation of potassium ion transmembrane transport, P:positive regulation of protein phosphatase type 2B activity, P:positive regulation of release of sequestered calcium ion into cytosol, P:positive regulation of ryanodine-sensitive calcium-release channel activity, P:protein targeting, P:regulation of action potential, P:regulation of membrane repolarization, P:regulation of protein kinase A signaling, P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, F:kinase activity, C:nuclear outer membrane, C:sarcoplasmic reticulum, F:protein kinase A binding, P:regulation of protein kinase A signaling cascade, C:protein complex
UniProtComplete proteome, Membrane, Nucleus, Polymorphism, Reference proteome, Repeat, Sarcoplasmic reticulum, Kinase, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.0449RNA microarray19698090
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.350.0010659RNA microarray23935909
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.271.87E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium