CKDdb-logoCKDdb - Molecule ID A0794

geneBMPR1A, ACVRLK3, ALK3
nameBone morphogenetic protein receptor type IA precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BMR1A_HUMANP36894ENSP00000361107657Hs.524477174900, 601299, 610069, 612242, 158350

Functions and classifications

GOC:dendrite, C:integral component of membrane, C:neuronal cell body, C:plasma membrane, F:ATP binding, F:metal ion binding, F:protein homodimerization activity, F:sequence-specific DNA binding RNA polymerase II transcription factor activity, F:SMAD binding, F:transforming growth factor beta-activated receptor activity, F:transmembrane receptor protein serine/threonine kinase activity, P:BMP signaling pathway, P:cartilage development, P:developmental growth, P:dorsal/ventral axis specification, P:ectoderm development, P:embryonic digit morphogenesis, P:embryonic organ development, P:endocardial cushion formation, P:heart formation, P:hindlimb morphogenesis, P:immune response, P:in utero embryonic development, P:lateral mesoderm development, P:lung development, P:mesendoderm development, P:mesoderm formation, P:Mullerian duct regression, P:negative regulation of neurogenesis, P:neural crest cell development, P:neural plate mediolateral regionalization, P:odontogenesis of dentin-containing tooth, P:palate development, P:paraxial mesoderm structural organization, P:pituitary gland development, P:positive regulation of bone mineralization, P:positive regulation of epithelial cell proliferation, P:positive regulation of mesenchymal cell proliferation, P:positive regulation of osteoblast differentiation, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:positive regulation of SMAD protein import into nucleus, P:positive regulation of transcription, DNA-templated, P:regulation of lateral mesodermal cell fate specification, P:somitogenesis, P:stem cell maintenance, P:transforming growth factor beta receptor signaling pathway, C:membrane, P:transmembrane receptor protein serine/threonine kinase signaling pathway, C:integral to membrane, P:positive regulation of transcription, DNA-dependent
UniProt3D-structure, ATP-binding, Complete proteome, Disease mutation, Disulfide bond, Glycoprotein, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Polymorphism, Receptor, Reference proteome, Serine/threonine-protein kinase, Signal, Transferase, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.33< 0.05RNA microarray21752957
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.43.85E-03RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.424.21E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.130.010112RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium