CKDdb-logoCKDdb - Molecule ID A0775

geneCASP3, CPP32
nameApopain precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASP3_HUMANP42574ENSP00000311032836Hs.141125600636

Functions and classifications

GOC:cytosol, C:mitochondrion, C:nucleoplasm, C:plasma membrane, F:aspartic-type endopeptidase activity, F:cyclin-dependent protein serine/threonine kinase inhibitor activity, F:cysteine-type endopeptidase activity involved in execution phase of apoptosis, P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, P:apoptotic DNA fragmentation, P:B cell homeostasis, P:cell fate commitment, P:cellular response to DNA damage stimulus, P:erythrocyte differentiation, P:extrinsic apoptotic signaling pathway in absence of ligand, P:extrinsic apoptotic signaling pathway via death domain receptors, P:glial cell apoptotic process, P:heart development, P:hippo signaling, P:intrinsic apoptotic signaling pathway, P:intrinsic apoptotic signaling pathway in response to oxidative stress, P:keratinocyte differentiation, P:negative regulation of activated T cell proliferation, P:negative regulation of apoptotic process, P:negative regulation of B cell proliferation, P:negative regulation of cyclin-dependent protein serine/threonine kinase activity, P:neuron apoptotic process, P:neurotrophin TRK receptor signaling pathway, P:platelet formation, P:positive regulation of apoptotic process, P:positive regulation of neuron apoptotic process, P:protein processing, P:proteolysis, P:release of cytochrome c from mitochondria, P:response to tumor necrosis factor, P:response to UV, P:response to wounding, P:sensory perception of sound, P:T cell homeostasis, F:cysteine-type endopeptidase activity, P:apoptotic process, C:nucleus, P:cellular response to organic substance, F:cyclin-dependent protein kinase inhibitor activity, P:apoptotic signaling pathway, P:hippo signaling cascade, P:induction of apoptosis, P:negative regulation of cyclin-dependent protein kinase activity, P:nerve growth factor receptor signaling pathway, P:nuclear fragmentation involved in apoptotic nuclear change, P:response to DNA damage stimulus, C:cytoplasm
UniProt3D-structure, Acetylation, Apoptosis, Complete proteome, Cytoplasm, Direct protein sequencing, Hydrolase, Phosphoprotein, Polymorphism, Protease, Reference proteome, S-nitrosylation, Thiol protease, Zymogen
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.73< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium