CKDdb-logoCKDdb - Molecule ID A0770

geneCACNA1C, CACNL1A1, CCHL1A1
nameVoltage-dependent L-type calcium channel subunit alpha-1C
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAC1C_HUMANQ13936ENSG00000151067775Hs.118262114205, 601005, 611875

Functions and classifications

GOC:caveolar macromolecular signaling complex, C:dendritic shaft, C:neuronal cell body, C:postsynaptic density, C:voltage-gated calcium channel complex, C:Z disc, F:metal ion binding, F:voltage-gated calcium channel activity, P:adult walking behavior, P:axon guidance, P:calcium ion transport into cytosol, P:calcium ion-dependent exocytosis, P:calcium-mediated signaling using extracellular calcium source, P:cell communication by electrical coupling involved in cardiac conduction, P:energy reserve metabolic process, P:glucose homeostasis, P:growth hormone secretion, P:insulin secretion, P:regulation of blood pressure, P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, P:regulation of insulin secretion, P:regulation of organ growth, P:regulation of vasoconstriction, P:small molecule metabolic process, P:smooth muscle contraction involved in micturition, P:synaptic transmission, P:visual learning, P:calcium ion transport, P:cellular calcium ion homeostasis, P:regulation of ion transmembrane transport, C:T-tubule
UniProt3D-structure, Alternative splicing, Brugada syndrome, Calcium, Calcium channel, Calcium transport, Cell membrane, Complete proteome, Disease mutation, Disulfide bond, Glycoprotein, Ion channel, Ion transport, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport, Voltage-gated channel
PADBchannel

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.270.000749RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.350.0307RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium