CKDdb-logoCKDdb - Molecule ID A0749

geneCASR, GPRC2A, PCAR1
nameExtracellular calcium-sensing receptor precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASR_HUMANP41180ENSG00000036828846Hs.435615145980, 239200, 601198, 601199, 612899, 146200

Functions and classifications

GOC:integral component of plasma membrane, F:G-protein coupled receptor activity, F:phosphatidylinositol phospholipase C activity, P:anatomical structure morphogenesis, P:calcium ion import, P:cellular calcium ion homeostasis, P:chemosensory behavior, P:detection of calcium ion, P:ossification, C:integral component of membrane, C:plasma membrane, C:apical plasma membrane, C:axon terminus, C:basolateral plasma membrane, C:cell surface, C:cytoplasm, C:neuronal cell body, C:nucleus, F:calcium ion binding, F:drug binding, F:magnesium ion binding, F:polyamine binding, P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, P:apoptotic process, P:branching morphogenesis of an epithelial tube, P:calcium ion transport, P:cellular response to glucose stimulus, P:cellular response to hepatocyte growth factor stimulus, P:cellular response to hypoxia, P:cellular response to low-density lipoprotein particle stimulus, P:cellular response to peptide, P:cellular response to vitamin D, P:fat pad development, P:JNK cascade, P:phospholipase C-activating G-protein coupled receptor signaling pathway, P:positive regulation of ATPase activity, P:positive regulation of calcium ion import, P:positive regulation of cell proliferation, P:positive regulation of gene expression, P:positive regulation of insulin secretion, P:positive regulation of positive chemotaxis, P:positive regulation of vasoconstriction, P:response to calcium ion, P:response to fibroblast growth factor, P:response to ischemia, P:vasodilation, C:integral to plasma membrane, C:integral to membrane, P:regulation of calcium ion transport
UniProtAlternative splicing, Cell membrane, Complete proteome, Disease mutation, Epilepsy, G-protein coupled receptor, Glycoprotein, Membrane, Polymorphism, Receptor, Reference proteome, Signal, Transducer, Transmembrane, Transmembrane helix, Ubl conjugation
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.460.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.340.014RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.473.23E-06RNA microarray20019191

Compile date 08-10-2018© iMODE-CKD consortium