CKDdb-logoCKDdb - Molecule ID A0740

geneAR, NR3C4, DHTR
nameAndrogen receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANDR_HUMANP10275ENSG00000169083367Hs.76704300068, 312300, 313200, 313700, 308370

Functions and classifications

GOC:axon, C:cytoplasm, C:dendrite, C:nuclear chromatin, C:nucleoplasm, C:plasma membrane, C:protein complex, F:androgen binding, F:androgen receptor activity, F:beta-catenin binding, F:chromatin binding, F:protein dimerization activity, F:sequence-specific DNA binding, F:transcription regulatory region DNA binding, F:zinc ion binding, P:activation of prostate induction by androgen receptor signaling pathway, P:cell death, P:cell growth, P:cell proliferation, P:cell-cell signaling, P:epithelial cell differentiation involved in prostate gland development, P:in utero embryonic development, P:lateral sprouting involved in mammary gland duct morphogenesis, P:male genitalia morphogenesis, P:male gonad development, P:male somatic sex determination, P:mammary gland alveolus development, P:morphogenesis of an epithelial fold, P:negative regulation of epithelial cell proliferation, P:negative regulation of extrinsic apoptotic signaling pathway, P:negative regulation of integrin biosynthetic process, P:organ formation, P:positive regulation of cell proliferation, P:positive regulation of insulin-like growth factor receptor signaling pathway, P:positive regulation of integrin biosynthetic process, P:positive regulation of intracellular estrogen receptor signaling pathway, P:positive regulation of MAPK cascade, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of phosphorylation, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of transcription from RNA polymerase III promoter, P:prostate gland development, P:prostate gland epithelium morphogenesis, P:prostate gland growth, P:protein oligomerization, P:regulation of catalytic activity, P:regulation of developmental growth, P:regulation of establishment of protein localization to plasma membrane, P:regulation of prostatic bud formation, P:regulation of systemic arterial blood pressure, P:response to insulin, P:sex differentiation, P:spermatogenesis, P:tertiary branching involved in mammary gland duct morphogenesis, P:transcription initiation from RNA polymerase II promoter, P:transport, C:nucleus, F:steroid binding, P:regulation of transcription from RNA polymerase II promoter, P:transcription from RNA polymerase II promoter, P:steroid hormone mediated signaling pathway, F:DNA binding, C:nucleus, F:sequence-specific DNA binding transcription factor activity, F:steroid hormone receptor activity, P:transcription, DNA-templated, F:metal ion binding, P:negative regulation of apoptotic process, P:response to insulin stimulus, P:transcription, DNA-dependent
UniProt3D-structure, Activator, Alternative splicing, Complete proteome, Cytoplasm, Disease mutation, DNA-binding, Isopeptide bond, Lipid-binding, Lipoprotein, Metal-binding, Neurodegeneration, Nucleus, Palmitate, Phosphoprotein, Polymorphism, Pseudohermaphroditism, Receptor, Reference proteome, Steroid-binding, Transcription, Transcription regulation, Triplet repeat expansion, Ubl conjugation, Zinc, Zinc-finger
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.350.0287RNA microarray19698090
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.190.0000664RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.360.018RNA microarray23291264
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.40.032315097LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.270.0000445RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium