CKDdb-logoCKDdb - Molecule ID A0712

geneBTK, AGMX1, ATK
nameTyrosine-protein kinase BTK
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BTK_HUMANQ06187ENSG00000010671695Hs.159494300300, 300755, 307200

Functions and classifications

GOC:cytoplasmic vesicle, C:cytosol, C:mast cell granule, C:membrane raft, C:nucleus, C:perinuclear region of cytoplasm, C:plasma membrane, F:ATP binding, F:metal ion binding, F:non-membrane spanning protein tyrosine kinase activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, P:adaptive immune response, P:apoptotic signaling pathway, P:B cell activation, P:B cell receptor signaling pathway, P:calcium-mediated signaling, P:cell maturation, P:Fc-epsilon receptor signaling pathway, P:histamine secretion by mast cell, P:I-kappaB kinase/NF-kappaB signaling, P:innate immune response, P:mesoderm development, P:MyD88-dependent toll-like receptor signaling pathway, P:positive regulation of B cell differentiation, P:positive regulation of NF-kappaB transcription factor activity, P:protein autophosphorylation, P:regulation of B cell apoptotic process, P:regulation of B cell cytokine production, P:response to organic substance, P:response to reactive oxygen species, P:toll-like receptor 2 signaling pathway, P:toll-like receptor 4 signaling pathway, P:toll-like receptor TLR1:TLR2 signaling pathway, P:toll-like receptor TLR6:TLR2 signaling pathway, P:transcription, DNA-templated, F:kinase activity, F:protein tyrosine kinase activity, P:peptidyl-tyrosine phosphorylation, F:protein kinase activity, P:intracellular signal transduction, C:intracellular membrane-bounded organelle, P:I-kappaB kinase/NF-kappaB cascade, P:Toll signaling pathway, P:toll-like receptor 1 signaling pathway, P:transcription, DNA-dependent, F:phospholipid binding, C:intracellular
UniProt3D-structure, Acetylation, Adaptive immunity, Apoptosis, ATP-binding, Cell membrane, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Immunity, Innate immunity, Kinase, Lipid-binding, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, SH2 domain, SH3 domain, Transcription, Transcription regulation, Transferase, Tyrosine-protein kinase, Zinc, Zinc-finger
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.090.000212RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.01< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.39< 0.05RNA-seq23757392
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.30.0000115RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium