CKDdb-logoCKDdb - Molecule ID A0704

geneARHGDIA, GDIA1
nameRho GDP-dissociation inhibitor 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
GDIR1_HUMANP52565ENSG00000141522396Hs.159161601925, 615244

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:immunological synapse, F:GTPase activator activity, F:Rho GDP-dissociation inhibitor activity, P:cellular component movement, P:negative regulation of apoptotic process, P:negative regulation of axonogenesis, P:negative regulation of cell adhesion, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of axonogenesis, P:positive regulation of GTPase activity, P:regulation of protein localization, P:regulation of small GTPase mediated signal transduction, P:Rho protein signal transduction, C:cytoplasm, P:regulation of catalytic activity, P:nerve growth factor receptor signaling pathway
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, GTPase activation, Phosphoprotein, Reference proteome
PADBdisease

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp18850734Canis lupus familiaris kidneydistal renal tubular cellskidney_calculi (Calcium oxalate monohydrate in vitro model)0.550.003Q-TOF MS/MS18850734
Exp19688724Mus musculus kidneypodocytesHigh_glucose_induced (High glucose in vitro model)0< 0.05MALDI-TOF-MS19688724
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.40.0067658RNA microarray19698090
Exp22007191Rattus norvegicus20kidneyglomeruliDiabetes (Diabetic Nephropathy)0.870.0413LC-ESI-MS/MS22007191
Exp22007191Rattus norvegicus20kidneyglomeruliDiabetes (Diabetic Nephropathy)1.280.041LC-ESI-MS/MS22007191
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.77 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23385635Homo sapiens14bloodperipheral blood mononuclear cell (PBMC)Fabry (Fabry)0.81250.001MALDI-TOF MS23385635
Exp24798088Rattus norvegicus kidney AKI (AKI)0.70.005MS/MS24798088
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)3.190.01403RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium