CKDdb-logoCKDdb - Molecule ID A0690

geneAP1S2, DC22
nameAdapter-related protein complex 1 sigma 1B subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AP1S2_HUMANP56377ENSG000001822878905Hs.121592300629, 300630, 603532

Functions and classifications

GOC:AP-type membrane coat adaptor complex, C:coated pit, C:cytoplasmic vesicle membrane, C:cytosol, C:Golgi membrane, C:lysosomal membrane, C:trans-Golgi network membrane, F:protein transporter activity, P:antigen processing and presentation of exogenous peptide antigen via MHC class II, P:intracellular protein transport, P:post-Golgi vesicle-mediated transport, P:regulation of defense response to virus by virus, P:viral process, C:membrane coat, P:vesicle-mediated transport, P:cellular membrane organization, P:endocytosis, P:viral reproduction
UniProtAlternative splicing, Coated pit, Complete proteome, Cytoplasmic vesicle, Golgi apparatus, Membrane, Mental retardation, Protein transport, Reference proteome, Transport, Endocytosis
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)2.4< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.40.00000288RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.810.00000656RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.912.26E-05RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.58< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.65< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.38< 0.05RNA-seq23757392
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.330.00000206RNA microarray24569379
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.331.04E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium