CKDdb-logoCKDdb - Molecule ID A0679

nameAlpha-2A adrenergic receptor
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:basolateral plasma membrane, C:cytoplasm, C:integral component of plasma membrane, C:receptor complex, C:synapse, F:alpha-1B adrenergic receptor binding, F:alpha2-adrenergic receptor activity, F:epinephrine binding, F:heterotrimeric G-protein binding, F:norepinephrine binding, F:protein heterodimerization activity, F:protein homodimerization activity, P:actin cytoskeleton organization, P:activation of MAPK activity by adrenergic receptor signaling pathway, P:activation of protein kinase B activity, P:acute inflammatory response, P:adenylate cyclase-inhibiting adrenergic receptor signaling pathway, P:cellular component movement, P:cellular response to hormone stimulus, P:DNA replication, P:energy reserve metabolic process, P:epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway, P:fear response, P:female pregnancy, P:glucose homeostasis, P:intestinal absorption, P:negative regulation of adenylate cyclase activity, P:negative regulation of adrenergic receptor signaling pathway, P:negative regulation of calcium ion transmembrane transporter activity, P:negative regulation of calcium ion transport, P:negative regulation of calcium ion-dependent exocytosis, P:negative regulation of epinephrine secretion, P:negative regulation of insulin secretion involved in cellular response to glucose stimulus, P:negative regulation of lipid catabolic process, P:negative regulation of norepinephrine secretion, P:negative regulation of uterine smooth muscle contraction, P:phospholipase C-activating adrenergic receptor signaling pathway, P:platelet activation, P:positive regulation of cell migration, P:positive regulation of cell proliferation, P:positive regulation of cytokine production, P:positive regulation of membrane protein ectodomain proteolysis, P:positive regulation of potassium ion transport, P:positive regulation of vasodilation, P:positive regulation of wound healing, P:regulation of vasoconstriction, P:Rho protein signal transduction, P:small molecule metabolic process, P:thermoception, C:integral to plasma membrane
UniProt3D-structure, Cell membrane, Complete proteome, Direct protein sequencing, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.220.00171RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.03< 0.05RNA microarray21752957
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.30.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium