CKDdb-logoCKDdb - Molecule ID A0647

geneANXA1, ANX1, LPC1
nameAnnexin A1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANXA1_HUMANP04083ENSG00000135046301Hs.494173151690

Functions and classifications

GOC:basolateral plasma membrane, C:cilium, C:cornified envelope, C:cytoplasm, C:extracellular space, C:extracellular vesicular exosome, C:mitochondrial membrane, C:nucleus, C:plasma membrane, C:protein complex, C:sarcolemma, F:calcium ion binding, F:calcium-dependent phospholipid binding, F:phospholipase A2 inhibitor activity, F:protein binding, bridging, F:receptor binding, F:structural molecule activity, P:alpha-beta T cell differentiation, P:arachidonic acid secretion, P:cell surface receptor signaling pathway, P:cellular component movement, P:cellular response to glucocorticoid stimulus, P:cellular response to hydrogen peroxide, P:endocrine pancreas development, P:estrous cycle phase, P:gliogenesis, P:hepatocyte differentiation, P:inflammatory response, P:insulin secretion, P:keratinocyte differentiation, P:negative regulation of acute inflammatory response, P:negative regulation of apoptotic process, P:negative regulation of protein secretion, P:neutrophil clearance, P:peptide cross-linking, P:positive regulation of G1/S transition of mitotic cell cycle, P:positive regulation of neutrophil apoptotic process, P:positive regulation of prostaglandin biosynthetic process, P:positive regulation of vesicle fusion, P:regulation of cell proliferation, P:response to drug, P:response to estradiol, P:response to interleukin-1, P:response to peptide hormone, P:response to X-ray, P:negative regulation of catalytic activity, P:neutrophil homeostasis, P:response to X-ray, F:phospholipase inhibitor activity, F:single-stranded DNA binding, F:single-stranded RNA binding, P:cell cycle, P:positive regulation of apoptotic process, P:response to estradiol stimulus, P:response to peptide hormone stimulus, P:response to glucocorticoid stimulus
UniProt3D-structure, Acetylation, Annexin, Calcium, Calcium/phospholipid-binding, Cell membrane, Cell projection, Cilium, Complete proteome, Cytoplasm, Direct protein sequencing, Isopeptide bond, Membrane, Nucleus, Phospholipase A2 inhibitor, Phosphoprotein, Reference proteome, Repeat
PADBinhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.73< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.15< 0.05cDNA microarray17003339
Exp17881425Mus musculus12urinewholeGlomerulonephritis (focal segmental glomerulosclerosis)  MALDI-TOF-MS17881425
Exp18850734Canis lupus familiaris kidneydistal renal tubular cellskidney_calculi (Calcium oxalate monohydrate in vitro model)0.620.037Q-TOF MS/MS18850734
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)5.460.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)4.450cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)132.01E-14RNA microarray19698090
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.08< 0.05LC-MS/MS19845401
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.433.23E-06RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.1 LC-MS/MS20543976
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.1 LC-MS/MS20543976
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)3.120cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.40cDNA microarray21411733
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)52.68< 0.05RNA microarray21752957
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)2.681.70E-03Nano RP-LC, MALDI-TOF22061828
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)4.680.000142RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.34< 0.05RNA-seq23757392
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0 1DE, MALDI24096133
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.550.032315097LC-MS/MS24172336
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)3.360.04LC-MS/MS24726496
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)3.780.007LC-MS/MS24726496
Exp25279147Homo sapiens12kidneybiopsy sectionGlomerulonephritis (IgA nephropathy)2.56< 0.05MALDI TOF/TOF25279147
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients)4.780.013495nanoLC-ESI-MS/MS25666440
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.190.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium