CKDdb-logoCKDdb - Molecule ID A0646

geneARHGEF7, COOL1, P85SPR
nameRho guanine nucleotide exchange factor 7
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHG7_HUMANQ14155ENSP000003259948874Hs.508738605477

Functions and classifications

GOC:cell cortex, C:cytosol, C:focal adhesion, C:lamellipodium, C:neuron projection, C:neuronal cell body, C:protein complex, C:ruffle, F:guanyl-nucleotide exchange factor activity, F:Rho guanyl-nucleotide exchange factor activity, P:apoptotic signaling pathway, P:epidermal growth factor receptor signaling pathway, P:lamellipodium assembly, P:negative regulation of epidermal growth factor receptor signaling pathway, P:nervous system development, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of GTPase activity, P:regulation of Rho GTPase activity, P:small GTPase mediated signal transduction, P:intracellular signal transduction, F:phospholipid binding, P:apoptotic process, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, P:regulation of small GTPase mediated signal transduction, C:intracellular
UniProt3D-structure, Alternative splicing, Cell junction, Cell projection, Complete proteome, Cytoplasm, Guanine-nucleotide releasing factor, Neurogenesis, Phosphoprotein, Polymorphism, Reference proteome, SH3 domain
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16372274Homo sapiens25urinewholeGlomerulonephritis (IgA nephropathy)0.09< 0.05MALDI-TOF-MS16372274

Compile date 08-10-2018© iMODE-CKD consortium