CKDdb-logoCKDdb - Molecule ID A0640

geneADRA1D, ADRA1A
nameAlpha-1D adrenergic receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA1D_HUMANP25100ENSG00000171873146Hs.557104219

Functions and classifications

GOC:integral component of plasma membrane, F:alpha1-adrenergic receptor activity, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, P:cell proliferation, P:cell-cell signaling, P:DNA metabolic process, P:multicellular organismal development, P:negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure, P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure, P:positive regulation of cell proliferation, C:integral component of membrane, C:plasma membrane, P:adrenergic receptor signaling pathway, C:integral to plasma membrane, C:integral to membrane
UniProtCell membrane, Complete proteome, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.00434RNA microarray19698090
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)2.30.0000588mRNA microarray23326503
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)3.55< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium