CKDdb-logoCKDdb - Molecule ID A0632

geneATF4, CREB2, TXREB
nameCyclic-AMP-dependent transcription factor ATF-4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATF4_HUMANP18848ENSG00000128272468Hs.496487604064

Functions and classifications

GOC:cytoplasm, C:dendrite membrane, C:microtubule organizing center, C:nucleoplasm, C:transcription factor complex, F:DNA binding, F:sequence-specific DNA binding, F:sequence-specific DNA binding transcription factor activity, P:activation of signaling protein activity involved in unfolded protein response, P:cellular amino acid metabolic process, P:cellular protein metabolic process, P:gamma-aminobutyric acid signaling pathway, P:gluconeogenesis, P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, P:negative regulation of potassium ion transport, P:positive regulation of neuron apoptotic process, P:positive regulation of transcription from RNA polymerase II promoter, P:transcription from RNA polymerase II promoter, C:nucleus, C:plasma membrane
UniProt3D-structure, Activator, Cell membrane, Coiled coil, Complete proteome, Cytoplasm, Cytoskeleton, DNA-binding, Lipoprotein, Membrane, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Transcription, Transcription regulation, Ubl conjugation
PADBTF: transcription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)3.040.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium