CKDdb-logoCKDdb - Molecule ID A0631

nameComplement component 1
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:cell surface, C:cytosol, C:extracellular space, C:mitochondrial matrix, C:mitochondrion, C:nucleolus, C:nucleus, C:plasma membrane, F:adrenergic receptor binding, F:complement component C1q binding, F:hyaluronic acid binding, F:kininogen binding, F:mitochondrial ribosome binding, F:mRNA binding, F:transcription corepressor activity, F:transcription factor binding, P:apoptotic process, P:blood coagulation, intrinsic pathway, P:complement activation, classical pathway, P:immune response, P:innate immune response, P:mature ribosome assembly, P:mRNA processing, P:negative regulation of defense response to virus, P:negative regulation of interferon-gamma production, P:negative regulation of interleukin-12 production, P:negative regulation of MDA-5 signaling pathway, P:negative regulation of mRNA splicing, via spliceosome, P:negative regulation of RIG-I signaling pathway, P:negative regulation of transcription from RNA polymerase II promoter, P:phosphatidylinositol 3-kinase signaling, P:positive regulation of apoptotic process, P:positive regulation of dendritic cell chemotaxis, P:positive regulation of mitochondrial translation, P:positive regulation of neutrophil chemotaxis, P:positive regulation of protein kinase B signaling, P:positive regulation of substrate adhesion-dependent cell spreading, P:positive regulation of trophoblast cell migration, P:regulation of complement activation, P:RNA splicing, P:transcription, DNA-templated, P:viral process, P:phosphatidylinositol 3-kinase cascade, P:positive regulation of protein kinase B signaling cascade, P:virus-host interaction
UniProt3D-structure, Acetylation, Adaptive immunity, Apoptosis, Cell membrane, Complement pathway, Complete proteome, Cytoplasm, Direct protein sequencing, Host-virus interaction, Immunity, Innate immunity, Membrane, Mitochondrion, mRNA processing, mRNA splicing, Nucleus, Phosphoprotein, Reference proteome, Ribosome biogenesis, Secreted, Transcription, Transcription regulation, Transit peptide

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp19369687Mus musculus kidneyproximal tubule cellsCyclosporine_A_induced (Ciclosporine A in vitro model)0.58< 0.02MALDI TOF/TOFWestern blot19369687
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.30.00000335RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.470.00000127RNA microarray 19698090
Exp19836472Mus musculus kidneytubule cellsDiabetes (Diabetic Nephropathy)0.16 LC-MS/MS 19836472
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap 20093355
Exp25667632Homo sapiens10kidneybiopsy sectionGlomerulonephritis (membranous nephropathy)0.65< 0.05MALDI-TOF/TOF 25667632
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.473.78E-03RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium