CKDdb-logoCKDdb - Molecule ID A0609

geneEgf
namePro-epidermal growth factor
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
EGF_MOUSEP01132ENSMUSG0000002801713645Mm.252481131530, 611718

Functions and classifications

GOC:extracellular region, C:extracellular space, C:integral component of membrane, C:lysosomal membrane, C:plasma membrane, F:calcium ion binding, F:epidermal growth factor receptor binding, F:protein binding, P:activation of MAPKK activity, P:angiogenesis, P:branching morphogenesis of an epithelial tube, P:epidermal growth factor receptor signaling pathway, P:ERK1 and ERK2 cascade, P:mammary gland alveolus development, P:negative regulation of cholesterol efflux, P:negative regulation of secretion, P:peptidyl-tyrosine phosphorylation, P:positive regulation of catenin import into nucleus, P:positive regulation of cell proliferation, P:positive regulation of cerebellar granule cell precursor proliferation, P:positive regulation of DNA binding, P:positive regulation of epidermal growth factor-activated receptor activity, P:positive regulation of hyaluronan biosynthetic process, P:positive regulation of MAP kinase activity, P:positive regulation of mitosis, P:positive regulation of peptidyl-threonine phosphorylation, P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, P:positive regulation of transcription, DNA-templated, P:regulation of calcium ion import, P:regulation of peptidyl-tyrosine phosphorylation, P:regulation of protein localization to cell surface, P:regulation of protein transport, P:STAT protein import into nucleus, C:integral to membrane, P:branching morphogenesis of a tube, P:positive regulation of transcription, DNA-dependent, P:regulation of protein secretion
UniProt3D-structure, Complete proteome, Direct protein sequencing, Disulfide bond, EGF-like domain, Glycoprotein, Growth factor, Membrane, Reference proteome, Repeat, Signal, Transmembrane, Transmembrane helix
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16549904Mus musculus10urinewholeGlomerulonephritis (membranoproliferative glomerulonephritis model)1.67 nano-LC-MS/MS16549904
Exp17095863Homo sapiens10urinewholeChronic_Renal_Insufficiency (Chronic kidney disease)1.05 Antibody Array17095863
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0 LC-MS/MS18440303
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.410.01cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.050.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.090.01cDNA microarray19099603
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.420.000486783RNA microarray20019191
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS20543976
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)0.75< 0.05LC-MS/MS20639044
Exp20639044bHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)1.23< 0.05LC-MS/MS20639044
Exp21595033bHomo sapiens14urineexosomesGlomerulonephritis (basement membrane nephropathy)0.470.00105LC-MS/MS21595033
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.04< 0.05RNA microarray21752957
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.480hybrid quadrupole-TOF, LC-MS/MS22536212
Exp22970174Mus musculus8kidneywholeChronic_Renal_Insufficiency (mouse_CKD_model)0.3< 0.05RNA microarray22970174
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)0.590.00003LC-MS/MS23228063
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.17 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23464927Homo sapiens10urine Fabry (12 months of ERT)0.94<0.05QTOF MS/MS23464927
Exp23506792bMus musculus10urinewholeDiclofenac_induced (diclofenac-induced renal injury) < 0.05MALDI-TOF MS23506792
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.26< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)0.5< 0.05RNA-seq23757392
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0.47 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0.42 1DE, MALDI24096133
Exp25578432aHomo sapiens60urinesupernatantDiabetes (type 2 diabetes without nephropathy)0.698E10-5LC-MS/MS25578432
Exp25578432bHomo sapiens42urinesupernatantDiabetes (type 2 diabetes with retinopathy)0.66E10-5LC-MS/MS25578432
Exp25578432cHomo sapiens51urinesupernatantDiabetes (diabetes with overt diabetic nephropathy)0.461.6E10-4LC-MS/MS25578432
Exp25957429Homo sapiens21urinewholeGlomerulonephritis (IgA nephropathy)0.32<0.05nano-LC-MS/MS25957429

Compile date 08-10-2018© iMODE-CKD consortium