CKDdb-logoCKDdb - Molecule ID A0606

geneATGR2, AGTR2
nameType-2 angiotensin II receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AGTR2_HUMANP50052ENSG00000180772186Hs.405348300034, 300852

Functions and classifications

GOC:extracellular region, C:integral component of plasma membrane, C:perinuclear region of cytoplasm, F:angiotensin type II receptor activity, F:peptide hormone binding, F:receptor antagonist activity, P:aldosterone secretion, P:behavior, P:blood vessel remodeling, P:brain development, P:brain renin-angiotensin system, P:cell growth involved in cardiac muscle cell development, P:cellular response to dexamethasone stimulus, P:cellular sodium ion homeostasis, P:cerebellar cortex development, P:dopamine biosynthetic process, P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, P:inflammatory response, P:negative regulation of blood vessel endothelial cell migration, P:negative regulation of cell growth, P:negative regulation of fibroblast proliferation, P:negative regulation of heart rate, P:negative regulation of icosanoid secretion, P:negative regulation of neurotrophin TRK receptor signaling pathway, P:negative regulation of norepinephrine secretion, P:nitric oxide mediated signal transduction, P:positive regulation of branching involved in ureteric bud morphogenesis, P:positive regulation of cell proliferation, P:positive regulation of cytokine secretion, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of metanephric glomerulus development, P:positive regulation of nitric oxide biosynthetic process, P:positive regulation of nitric-oxide synthase activity, P:positive regulation of phosphoprotein phosphatase activity, P:positive regulation of renal sodium excretion, P:positive regulation of transcription, DNA-templated, P:positive regulation of vasodilation, P:regulation of metanephros size, P:regulation of systemic arterial blood pressure by circulatory renin-angiotensin, P:regulation of transcription factor import into nucleus, P:renin-angiotensin regulation of aldosterone production, P:response to organonitrogen compound, P:vasodilation by angiotensin involved in regulation of systemic arterial blood pressure, C:integral component of membrane, C:plasma membrane, P:angiotensin-activated signaling pathway, P:regulation of apoptotic process, C:integral to plasma membrane, P:intracellular protein kinase cascade, P:negative regulation of nerve growth factor receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of transcription, DNA-dependent, C:integral to membrane
UniProtCell membrane, Complete proteome, Disease mutation, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Mental retardation, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.180.000225RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium