CKDdb-logoCKDdb - Molecule ID A0593

geneCACNA1A, CACH4, CACN3
nameVoltage-dependent P/Q-type calcium channel alpha-1A subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAC1A_HUMANO00555ENSG00000141837773Hs.501632108500, 141500, 183086, 601011

Functions and classifications

GOC:cell projection, C:cytoplasm, C:dendrite, C:integral component of membrane, C:neuronal cell body, C:nucleus, C:plasma membrane, C:voltage-gated calcium channel complex, F:high voltage-gated calcium channel activity, F:metal ion binding, F:syntaxin binding, F:voltage-gated calcium channel activity, P:adult walking behavior, P:behavioral response to pain, P:calcium ion-dependent exocytosis, P:calcium ion-dependent exocytosis of neurotransmitter, P:cell death, P:cell growth, P:cellular chloride ion homeostasis, P:cerebellar molecular layer development, P:cerebellar Purkinje cell differentiation, P:cerebellum maturation, P:dendrite morphogenesis, P:energy reserve metabolic process, P:gamma-aminobutyric acid secretion, P:gamma-aminobutyric acid signaling pathway, P:glucose metabolic process, P:hormone metabolic process, P:membrane depolarization, P:musculoskeletal movement, spinal reflex action, P:negative regulation of hormone biosynthetic process, P:negative regulation of neuron apoptotic process, P:neuromuscular process controlling balance, P:neuromuscular synaptic transmission, P:neurotransmitter metabolic process, P:positive regulation of cytosolic calcium ion concentration, P:receptor clustering, P:regulation of acetylcholine secretion, neurotransmission, P:regulation of axonogenesis, P:regulation of calcium ion-dependent exocytosis, P:regulation of insulin secretion, P:rhythmic synaptic transmission, P:small molecule metabolic process, P:spinal cord motor neuron differentiation, P:sulfur amino acid metabolic process, P:synapse assembly, P:synaptic transmission, P:synaptic transmission, glutamatergic, P:vestibular nucleus development, C:dendrite, P:regulation of ion transmembrane transport, F:calcium ion binding, C:integral to membrane, C:perikaryon, P:elevation of cytosolic calcium ion concentration, P:regulation of acetylcholine secretion, F:ion channel activity, P:ion transmembrane transport
UniProt3D-structure, Alternative splicing, Calcium, Calcium channel, Calcium transport, Complete proteome, Disease mutation, Disulfide bond, Glycoprotein, Ion channel, Ion transport, Membrane, Metal-binding, Neurodegeneration, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Spinocerebellar ataxia, Transmembrane, Transmembrane helix, Transport, Triplet repeat expansion, Voltage-gated channel
PADBchannel

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.000000128RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0143RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium