CKDdb-logoCKDdb - Molecule ID A0587

geneADD2, ADDB
nameBeta adducin
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADDB_HUMANP35612ENSG00000075340119Hs.188528102681

Functions and classifications

GOC:cytoplasmic membrane-bounded vesicle, C:F-actin capping protein complex, C:plasma membrane, F:actin filament binding, F:spectrin binding, F:structural molecule activity, P:actin filament bundle assembly, P:barbed-end actin filament capping, P:hemopoiesis, P:positive regulation of protein binding, P:protein complex assembly, C:cytoskeleton, C:membrane, C:cytoplasm, F:metal ion binding, P:ion transport
UniProtActin-binding, Alternative splicing, Calmodulin-binding, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Membrane, Phosphoprotein, Polymorphism, Reference proteome, Acetylation
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.0000987RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.0129RNA microarray19698090
Exp20706631Mus musculus6kidneyglomerular capillary endothelial cellDiabetes (diabetic nephropathy)0.45< 0.05RNA microarray20706631
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.710.00000178RNA microarray24569379
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.282.71E-03RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.296.66E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.39.59E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)2.771.99E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.015306RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium