CKDdb-logoCKDdb - Molecule ID A0558

geneB-raf, BRAF, BRAF1
nameB-Raf proto-oncogene serine/threonine-protein kinase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BRAF_HUMANP15056ENSG00000157764673Hs.550061114500, 115150, 164757, 211980, 605027, 613706, 613707

Functions and classifications

GOC:cytosol, C:neuron projection, C:nucleus, C:plasma membrane, F:ATP binding, F:calcium ion binding, F:MAP kinase kinase kinase activity, F:protein serine/threonine kinase activity, P:activation of MAPKK activity, P:cellular response to calcium ion, P:fibroblast growth factor receptor signaling pathway, P:negative regulation of apoptotic process, P:negative regulation of neuron apoptotic process, P:neurotrophin TRK receptor signaling pathway, P:organ morphogenesis, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of gene expression, P:positive regulation of peptidyl-serine phosphorylation, P:protein heterooligomerization, P:response to cAMP, P:response to epidermal growth factor, P:response to peptide hormone, P:small GTPase mediated signal transduction, P:synaptic transmission, F:protein kinase activity, C:cytoplasm, F:kinase activity, F:transferase activity, P:metabolic process, F:receptor signaling protein activity, P:intracellular signal transduction, P:nerve growth factor receptor signaling pathway, P:response to epidermal growth factor stimulus, P:response to peptide hormone stimulus
UniProt3D-structure, Acetylation, ATP-binding, Cardiomyopathy, Cell membrane, Chromosomal rearrangement, Complete proteome, Cytoplasm, Deafness, Direct protein sequencing, Disease mutation, Ectodermal dysplasia, Isopeptide bond, Kinase, Membrane, Mental retardation, Metal-binding, Methylation, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, Serine/threonine-protein kinase, Transferase, Ubl conjugation, Zinc, Zinc-finger
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.00199RNA microarray19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.020.022973399LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.363.26E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium