CKDdb-logoCKDdb - Molecule ID A0554

geneBcl2l11, Bim
nameBcl-2-like protein 11
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
B2L11_MOUSEO54918ENSMUSG0000002738112125Mm.141083603827

Functions and classifications

GOC:BIM-BCL-2 complex, C:BIM-BCL-xl complex, C:cytoplasm, C:cytosol, C:extrinsic component of membrane, C:intracellular membrane-bounded organelle, C:microtubule, C:mitochondrion, F:microtubule binding, F:protein binding, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:apoptotic process involved in embryonic digit morphogenesis, P:B cell apoptotic process, P:B cell homeostasis, P:brain development, P:cell-matrix adhesion, P:cellular process regulating host cell cycle in response to virus, P:developmental pigmentation, P:ear development, P:extrinsic apoptotic signaling pathway in absence of ligand, P:in utero embryonic development, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:kidney development, P:leukocyte homeostasis, P:lymphocyte homeostasis, P:male gonad development, P:mammary gland development, P:myeloid cell homeostasis, P:odontogenesis of dentin-containing tooth, P:positive regulation of apoptotic process, P:positive regulation of apoptotic process by virus, P:positive regulation of cell cycle, P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:positive regulation of fibroblast apoptotic process, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of mitochondrial membrane permeability involved in apoptotic process, P:positive regulation of neuron apoptotic process, P:positive regulation of protein homooligomerization, P:positive regulation of release of cytochrome c from mitochondria, P:post-embryonic development, P:post-embryonic organ morphogenesis, P:regulation of apoptotic process, P:regulation of developmental pigmentation, P:regulation of organ growth, P:response to endoplasmic reticulum stress, P:spermatogenesis, P:spleen development, P:T cell homeostasis, P:thymocyte apoptotic process, P:thymus development, P:tube formation, C:cytoplasm, C:extrinsic component of membrane, C:intracellular membrane-bounded organelle, C:mitochondrion, F:microtubule binding, F:protein binding, P:apoptotic process involved in embryonic digit morphogenesis, P:B cell apoptotic process, P:B cell homeostasis, P:cell-matrix adhesion, P:cellular process regulating host cell cycle in response to virus, P:developmental pigmentation, P:ear development, P:extrinsic apoptotic signaling pathway in absence of ligand, P:in utero embryonic development, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:kidney development, P:leukocyte homeostasis, P:lymphocyte homeostasis, P:male gonad development, P:mammary gland development, P:myeloid cell homeostasis, P:odontogenesis of dentin-containing tooth, P:positive regulation of apoptotic process, P:positive regulation of apoptotic process by virus, P:positive regulation of cell cycle, P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:positive regulation of mitochondrial membrane permeability involved in apoptotic process, P:positive regulation of neuron apoptotic process, P:post-embryonic development, P:post-embryonic organ morphogenesis, P:regulation of apoptotic process, P:regulation of developmental pigmentation, P:regulation of organ growth, P:spermatogenesis, P:spleen development, P:T cell homeostasis, P:thymocyte apoptotic process, P:thymus development, P:tube formation, C:cytoplasm, C:extrinsic component of membrane, C:intracellular membrane-bounded organelle, C:mitochondrion, F:microtubule binding, F:protein binding, P:apoptotic process involved in embryonic digit morphogenesis, P:B cell apoptotic process, P:B cell homeostasis, P:cell-matrix adhesion, P:cellular process regulating host cell cycle in response to virus, P:developmental pigmentation, P:ear development, P:extrinsic apoptotic signaling pathway in absence of ligand, P:in utero embryonic development, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:kidney development, P:leukocyte homeostasis, P:lymphocyte homeostasis, P:male gonad development, P:mammary gland development, P:myeloid cell homeostasis, P:odontogenesis of dentin-containing tooth, P:positive regulation of apoptotic process, P:positive regulation of apoptotic process by virus, P:positive regulation of cell cycle, P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:positive regulation of mitochondrial membrane permeability involved in apoptotic process, P:positive regulation of neuron apoptotic process, P:post-embryonic development, P:post-embryonic organ morphogenesis, P:regulation of apoptotic process, P:regulation of developmental pigmentation, P:regulation of organ growth, P:spermatogenesis, P:spleen development, P:T cell homeostasis, P:thymocyte apoptotic process, P:thymus development, P:tube formation, C:cytoplasm, C:extrinsic component of membrane, C:intracellular membrane-bounded organelle, C:mitochondrion, F:microtubule binding, F:protein binding, P:apoptotic process involved in embryonic digit morphogenesis, P:B cell apoptotic process, P:B cell homeostasis, P:cell-matrix adhesion, P:cellular process regulating host cell cycle in response to virus, P:developmental pigmentation, P:ear development, P:extrinsic apoptotic signaling pathway in absence of ligand, P:in utero embryonic development, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:kidney development, P:leukocyte homeostasis, P:lymphocyte homeostasis, P:male gonad development, P:mammary gland development, P:myeloid cell homeostasis, P:odontogenesis of dentin-containing tooth, P:positive regulation of apoptotic process, P:positive regulation of apoptotic process by virus, P:positive regulation of cell cycle, P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:positive regulation of mitochondrial membrane permeability involved in apoptotic process, P:positive regulation of neuron apoptotic process, P:post-embryonic development, P:post-embryonic organ morphogenesis, P:regulation of apoptotic process, P:regulation of developmental pigmentation, P:regulation of organ growth, P:spermatogenesis, P:spleen development, P:T cell homeostasis, P:thymocyte apoptotic process, P:thymus development, P:tube formation
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Membrane, Mitochondrion, Phosphoprotein, Reference proteome, Ubl conjugation
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19688726aRattus norvegicuskidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)4 MALDI-TOF19688726
Exp19688726bRattus norvegicuskidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)2.14 MALDI-TOF19688726
Exp24569379Mus musculuskidneyendothelial cellsAKI (AKI)3.210.00000118RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium