CKDdb-logoCKDdb - Molecule ID A0548

geneBAX, BCL2L4
nameApoptosis regulator BAX
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BAX_HUMANQ07812ENSG00000087088581Hs.624291600040

Functions and classifications

GOC:BAX complex, C:cytosol, C:endoplasmic reticulum membrane, C:mitochondrial outer membrane, C:mitochondrial permeability transition pore complex, C:nucleus, F:BH3 domain binding, F:channel activity, F:lipid binding, F:protein homodimerization activity, P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, P:apoptotic process involved in embryonic digit morphogenesis, P:apoptotic process involved in patterning of blood vessels, P:B cell homeostasis, P:B cell homeostatic proliferation, P:B cell negative selection, P:B cell receptor apoptotic signaling pathway, P:blood vessel remodeling, P:cellular response to organic substance, P:cellular response to UV, P:cerebral cortex development, P:development of secondary sexual characteristics, P:endoplasmic reticulum calcium ion homeostasis, P:establishment or maintenance of transmembrane electrochemical gradient, P:extrinsic apoptotic signaling pathway in absence of ligand, P:extrinsic apoptotic signaling pathway via death domain receptors, P:fertilization, P:germ cell development, P:germ cell programmed cell death, P:glycosphingolipid metabolic process, P:homeostasis of number of cells within a tissue, P:hypothalamus development, P:intrinsic apoptotic signaling pathway by p53 class mediator, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, P:kidney development, P:mitochondrial fragmentation involved in apoptotic process, P:mitochondrial fusion, P:myeloid cell homeostasis, P:negative regulation of apoptotic signaling pathway, P:negative regulation of endoplasmic reticulum calcium ion concentration, P:negative regulation of fibroblast proliferation, P:negative regulation of neuron apoptotic process, P:negative regulation of peptidyl-serine phosphorylation, P:negative regulation of protein binding, P:neuron apoptotic process, P:neuron migration, P:nuclear fragmentation involved in apoptotic nuclear change, P:odontogenesis of dentin-containing tooth, P:ovarian follicle development, P:positive regulation of apoptotic DNA fragmentation, P:positive regulation of apoptotic process involved in mammary gland involution, P:positive regulation of B cell apoptotic process, P:positive regulation of developmental pigmentation, P:positive regulation of endoplasmic reticulum unfolded protein response, P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of mitochondrial outer membrane permeabilization, P:positive regulation of neuron apoptotic process, P:positive regulation of protein oligomerization, P:positive regulation of release of cytochrome c from mitochondria, P:positive regulation of release of sequestered calcium ion into cytosol, P:post-embryonic camera-type eye morphogenesis, P:protein homooligomerization, P:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, P:regulation of cell cycle, P:regulation of mammary gland epithelial cell proliferation, P:regulation of mitochondrial membrane potential, P:regulation of nitrogen utilization, P:regulation of protein heterodimerization activity, P:regulation of protein homodimerization activity, P:release of cytochrome c from mitochondria, P:release of matrix enzymes from mitochondria, P:response to acid, P:response to axon injury, P:response to gamma radiation, P:response to salt stress, P:response to toxic substance, P:retina development in camera-type eye, P:retinal cell apoptotic process, P:retinal cell programmed cell death, P:Sertoli cell proliferation, P:spermatid differentiation, P:T cell homeostatic proliferation, P:thymocyte apoptotic process, P:transformed cell apoptotic process, P:vagina development, P:viral process, C:endoplasmic reticulum, P:B cell apoptotic process, P:positive regulation of apoptotic process, C:Bcl-2 family protein complex, C:cytosolic part, P:apoptotic DNA fragmentation, P:cleavage of lamin involved in execution phase of apoptosis, P:induction of apoptosis, P:limb morphogenesis, P:reduction of endoplasmic reticulum calcium ion concentration, P:response to DNA damage stimulus, P:response to toxin, P:virus-host interaction
UniProt3D-structure, Acetylation, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Host-virus interaction, Membrane, Mitochondrion, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Tumor suppressor
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)3.6< 0.01RNA microarray15042541
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.330.0000067RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)5.620.0000133RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium