CKDdb-logoCKDdb - Molecule ID A0547

geneCASP8, MCH5
nameCaspase-8 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASP8_HUMANQ14790ENSG00000064012841Hs.599762211980, 601763, 607271

Functions and classifications

GOC:CD95 death-inducing signaling complex, C:cell body, C:centrosome, C:cytosol, C:death-inducing signaling complex, C:membrane raft, C:mitochondrial outer membrane, C:neuron projection, C:Noc1p-Noc2p complex, C:nucleus, C:ripoptosome, F:cysteine-type endopeptidase activity involved in apoptotic process, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:angiogenesis, P:B cell activation, P:cellular component disassembly involved in execution phase of apoptosis, P:cellular response to mechanical stimulus, P:cellular response to organic cyclic compound, P:extrinsic apoptotic signaling pathway, P:extrinsic apoptotic signaling pathway via death domain receptors, P:heart development, P:hepatocyte apoptotic process, P:innate immune response, P:intrinsic apoptotic signaling pathway, P:macrophage differentiation, P:natural killer cell activation, P:negative regulation of I-kappaB kinase/NF-kappaB signaling, P:neural tube formation, P:nucleotide-binding oligomerization domain containing signaling pathway, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of macrophage differentiation, P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, P:positive regulation of proteolysis, P:protein heterooligomerization, P:proteolysis involved in cellular protein catabolic process, P:regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:regulation of thymocyte apoptotic process, P:response to antibiotic, P:response to cobalt ion, P:response to cold, P:response to estradiol, P:response to ethanol, P:response to lipopolysaccharide, P:response to tumor necrosis factor, P:syncytiotrophoblast cell differentiation involved in labyrinthine layer development, P:T cell activation, P:toll-like receptor 3 signaling pathway, P:toll-like receptor 4 signaling pathway, P:TRIF-dependent toll-like receptor signaling pathway, P:viral process, F:cysteine-type endopeptidase activity, P:proteolysis, P:regulation of apoptotic process, C:mitochondrion, P:apoptotic process, P:negative regulation of I-kappaB kinase/NF-kappaB cascade, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:response to estradiol stimulus, P:virus-host interaction
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Host-virus interaction, Hydrolase, Phosphoprotein, Polymorphism, Protease, Reference proteome, Repeat, Thiol protease, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.40.0000289RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.44< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.07< 0.05RNA microarray21752957
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.336.27E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.369.06E-05RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.120.003853RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium