CKDdb-logoCKDdb - Molecule ID A0537

geneANXA2, ANX2, ANX2L4
nameAnnexin A2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANXA2_HUMANP07355ENSG00000182718302Hs.511605151740

Functions and classifications

GOC:basement membrane, C:cell cortex, C:early endosome, C:extracellular vesicular exosome, C:extrinsic component of plasma membrane, C:lipid particle, C:macropinosome, C:melanosome, C:midbody, C:myelin sheath adaxonal region, C:perinuclear region of cytoplasm, C:protein complex, C:ruffle, C:sarcolemma, C:Schmidt-Lanterman incisure, F:calcium ion binding, F:calcium-dependent phospholipid binding, F:phosphatidylinositol-4,5-bisphosphate binding, F:phospholipase inhibitor activity, P:angiogenesis, P:body fluid secretion, P:cellular response to acid, P:collagen fibril organization, P:fibrinolysis, P:negative regulation of catalytic activity, P:positive regulation of binding, P:positive regulation of fibroblast proliferation, P:positive regulation of protein phosphorylation, P:positive regulation of vesicle fusion, P:protein targeting to plasma membrane, C:cell cortex, C:vesicle, C:extrinsic to plasma membrane, C:plasma membrane, P:skeletal system development, C:early endosome, P:positive regulation of binding
UniProt3D-structure, Acetylation, Alternative splicing, Annexin, Basement membrane, Calcium, Calcium/phospholipid-binding, Complete proteome, Direct protein sequencing, Extracellular matrix, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Ubl conjugation
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.96< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.31< 0.05cDNA microarray17003339
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.260.0000126RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.270.0000157RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.390.00000467RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)0.02< 0.05LC-MS/MS20639044
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)0.76< 0.05LC-MS/MS20940332
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.320cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.390cDNA microarray21411733
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)11.07< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)11.84< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)12.58< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.15< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.15< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.15< 0.05RNA microarray21752957
Exp22159597Rattus norvegicus30kidneyglomeruliGlomerulonephritis (mesangial proliferative glomerulonephritis) 0.0017LC-MS22159597
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)4.280.000151RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)7.90.000351RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.24< 0.05RNA-seq23757392
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)0.33 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp24211404Homo sapiens16urineexosomeDiabetes (diabetic nephropathy)0.440.0092LC-MS/MS24211404
Exp25578432aHomo sapiens60urinesupernatantDiabetes (type 2 diabetes without nephropathy)1.140.58LC-MS/MS25578432
Exp25578432bHomo sapiens42urinesupernatantDiabetes (type 2 diabetes with retinopathy)1.990.03LC-MS/MS25578432
Exp25578432cHomo sapiens51urinesupernatantDiabetes (diabetes with overt diabetic nephropathy)0.680.67LC-MS/MS25578432
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients)6.310.005963nanoLC-ESI-MS/MS25666440

Compile date 08-10-2018© iMODE-CKD consortium