CKDdb-logoCKDdb - Molecule ID A0523

geneAPBB1, FE65, RIR
nameAmyloid beta A4 precursor protein-binding family B member 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APBB1_HUMANO00213ENSG00000166313322Hs.372840602709

Functions and classifications

GOC:cytoplasm, C:growth cone, C:lamellipodium, C:nuclear speck, C:nucleus, C:plasma membrane, C:synapse, F:beta-amyloid binding, F:chromatin binding, F:transcription factor binding, P:apoptotic process, P:axon guidance, P:axonogenesis, P:cell cycle arrest, P:cellular response to DNA damage stimulus, P:double-strand break repair, P:extracellular matrix organization, P:histone H4 acetylation, P:negative regulation of cell growth, P:negative regulation of neuron differentiation, P:negative regulation of thymidylate synthase biosynthetic process, P:neuron migration, P:positive regulation of apoptotic process, P:positive regulation of DNA repair, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of transcription, DNA-templated, P:signal transduction, P:transcription, DNA-templated, P:visual learning, C:growth cone, P:regulation of transcription, DNA-templated, C:dendritic spine, C:perinuclear region of cytoplasm, C:postsynaptic membrane, C:presynaptic membrane, C:protein complex, P:negative regulation of S phase of mitotic cell cycle, P:positive regulation of protein secretion, P:positive regulation of transcription, DNA-dependent, P:response to DNA damage stimulus, P:response to iron ion, P:transcription, DNA-dependent, P:regulation of transcription, DNA-dependent
UniProt3D-structure, Activator, Alternative splicing, Apoptosis, Cell membrane, Cell projection, Chromatin regulator, Complete proteome, Cytoplasm, DNA damage, Membrane, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Repressor, Transcription, Transcription regulation
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.180cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.340.00134RNA microarray19698090
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)3.40.013999RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.380.009839RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium