CKDdb-logoCKDdb - Molecule ID A0518

geneGhr, GHR/BP
nameGrowth hormone receptor
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
GHR_RATP16310ENSRNOG0000001565425235Rn.2178143890, 262500, 600946, 604271

Functions and classifications

GOC:cell surface, C:cytoplasm, C:extracellular space, C:extrinsic component of membrane, C:growth hormone receptor complex, C:integral component of plasma membrane, C:mitochondrion, C:neuronal cell body, C:nucleus, C:plasma membrane, F:growth hormone receptor activity, F:peptide hormone binding, F:protein kinase binding, F:protein phosphatase binding, F:SH2 domain binding, P:activation of JAK2 kinase activity, P:activation of Janus kinase activity, P:activation of MAPK activity, P:cartilage development involved in endochondral bone morphogenesis, P:cellular response to insulin stimulus, P:cytokine-mediated signaling pathway, P:growth hormone receptor signaling pathway, P:hormone-mediated signaling pathway, P:insulin-like growth factor receptor signaling pathway, P:JAK-STAT cascade, P:multicellular organismal metabolic process, P:negative regulation of neuron death, P:positive regulation of cell differentiation, P:positive regulation of JAK-STAT cascade, P:positive regulation of multicellular organism growth, P:receptor internalization, P:response to cycloheximide, P:response to cytokine, P:response to estradiol, P:response to food, P:response to glucocorticoid, P:response to hormone, P:response to interleukin-1, P:response to morphine, P:response to peptide hormone, C:extrinsic to membrane, C:integral to plasma membrane, P:response to estradiol stimulus, P:response to glucocorticoid stimulus, C:membrane, F:cytokine receptor activity, C:cell surface, C:extrinsic component of membrane, C:growth hormone receptor complex, C:integral component of plasma membrane, C:nucleus, F:growth hormone receptor activity, F:peptide hormone binding, P:cellular response to hormone stimulus, P:insulin-like growth factor receptor signaling pathway, P:multicellular organismal metabolic process, P:positive regulation of multicellular organism growth, P:receptor internalization, P:response to cycloheximide, P:response to estradiol, C:extracellular space, C:extrinsic to membrane, C:integral to plasma membrane, P:growth hormone receptor signaling pathway, P:response to estradiol stimulus, , , , C:membrane, F:cytokine receptor activity, P:cytokine-mediated signaling pathway, C:cell surface, C:extracellular space, C:extrinsic to membrane, C:growth hormone receptor complex, C:integral to plasma membrane, C:nucleus, F:growth hormone receptor activity, F:peptide hormone binding, P:cytokine-mediated signaling pathway, P:growth hormone receptor signaling pathway, P:insulin-like growth factor receptor signaling pathway, P:multicellular organismal metabolic process, P:positive regulation of multicellular organism growth, P:receptor internalization, P:response to cycloheximide, P:response to estradiol stimulus, C:membrane, F:cytokine receptor activity, P:cytokine-mediated signaling pathway
UniProtAlternative splicing, Cell membrane, Complete proteome, Disulfide bond, Endocytosis, Glycoprotein, Membrane, Phosphoprotein, Receptor, Reference proteome, Secreted, Signal, Transmembrane, Transmembrane helix, Ubl conjugation, , , , , , , ,
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.52< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.56< 0.05cDNA microarray17003339
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)8.3< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)3.1< 0.05RNA microarray18187931
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.470.04cDNA microarray19099603
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.440.0863RNA microarray20847290
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.09< 0.05RNA microarray21752957
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.130.000286RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.230.000597RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.36< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium