CKDdb-logoCKDdb - Molecule ID A0508

geneATP2B2, PMCA2, PMCA2I
namePlasma membrane calcium-transporting ATPase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AT2B2_HUMANQ01814ENSG00000157087491Hs.268942108733

Functions and classifications

GOC:apical plasma membrane, C:cilium, C:cytoplasm, C:endoplasmic reticulum, C:integral component of membrane, C:neuronal cell body, C:plasma membrane, F:ATP binding, F:calcium ion binding, F:calcium-dependent ATPase activity, F:calcium-transporting ATPase activity, F:calmodulin binding, F:metal ion binding, F:PDZ domain binding, P:auditory receptor cell stereocilium organization, P:blood coagulation, P:cerebellar granule cell differentiation, P:cerebellar Purkinje cell differentiation, P:cGMP metabolic process, P:cochlea development, P:cytosolic calcium ion homeostasis, P:detection of mechanical stimulus involved in sensory perception of sound, P:lactation, P:locomotion, P:locomotory behavior, P:neuromuscular process controlling balance, P:neuron differentiation, P:organelle organization, P:otolith mineralization, P:positive regulation of calcium ion transport, P:regulation of cell size, P:regulation of synaptic plasticity, P:sensory perception of sound, P:serotonin metabolic process, P:synapse organization, P:ATP catabolic process, P:calcium ion transport, P:calcium ion transmembrane transport, F:cation-transporting ATPase activity, P:ion transmembrane transport, C:dendrite, C:integral to membrane, C:membrane raft, P:ATP biosynthetic process, P:neural retina development, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:cation transport
UniProtAlternative splicing, ATP-binding, Calcium, Calcium transport, Calmodulin-binding, Cell membrane, Complete proteome, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.480.0498879RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.170.000169RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.0199RNA microarray19698090
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.38< 0.05LC-MS/MS19845401
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.350.022108183LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium