CKDdb-logoCKDdb - Molecule ID A0488

geneARNT, BHLHE2
nameAryl hydrocarbon receptor nuclear translocator
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARNT_HUMANP27540ENSG00000143437405Hs.632446126110

Functions and classifications

GOC:cytoplasm, C:nucleoplasm, C:transcription factor complex, F:aryl hydrocarbon receptor activity, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, F:transcription coactivator activity, P:cell differentiation, P:embryonic placenta development, P:mRNA transcription from RNA polymerase II promoter, P:positive regulation of endothelial cell proliferation, P:positive regulation of erythrocyte differentiation, P:positive regulation of glycolysis, P:positive regulation of hormone biosynthetic process, P:positive regulation of protein sumoylation, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of transcription, DNA-templated, P:positive regulation of vascular endothelial growth factor receptor signaling pathway, P:positive regulation vascular endothelial growth factor production, P:regulation of transcription from RNA polymerase II promoter in response to hypoxia, P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress, C:nucleus, F:signal transducer activity, P:transcription, DNA-templated, F:sequence-specific DNA binding, P:positive regulation of transcription, DNA-dependent, P:transcription, DNA-dependent, P:regulation of transcription, DNA-dependent, P:signal transduction
UniProt3D-structure, Acetylation, Activator, Alternative splicing, Complete proteome, Direct protein sequencing, DNA-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transcription, Transcription regulation, Receptor
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19139726Homo sapiens21kidneyproximal tubuleproteinuria (proteinuria)3.36< 0.05cDNA microarray19139726
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.00067RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.14< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium