CKDdb-logoCKDdb - Molecule ID A047J

geneTxnip
nameThioredoxin-interacting protein
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
TXNIP_MOUSEQ8BG60ENSMUSG0000003839356338Mm.410189606599

Functions and classifications

GOC:cytoplasm, C:cytosol, C:mitochondrial intermembrane space, C:nucleus, F:enzyme inhibitor activity, F:protein binding, P:cell cycle, P:cellular response to tumor cell, P:keratinocyte differentiation, P:negative regulation of catalytic activity, P:negative regulation of cell division, P:negative regulation of transcription from RNA polymerase II promoter, P:platelet-derived growth factor receptor signaling pathway, P:positive regulation of apoptotic process, P:protein import into nucleus, P:regulation of cell proliferation, P:response to calcium ion, P:response to drug, P:response to estradiol, P:response to glucose, P:response to hydrogen peroxide, P:response to mechanical stimulus, P:response to oxidative stress, P:response to progesterone, P:transcription, DNA-templated
UniProtAlternative splicing, Cell cycle, Complete proteome, Cytoplasm, Disulfide bond, Isopeptide bond, Phosphoprotein, Reference proteome, Transcription, Transcription regulation, Tumor suppressor, Ubl conjugation
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.96< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.3< 0.05cDNA microarray17003339
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.995.52E-06RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.03< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.26< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)8.51< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium