CKDdb-logoCKDdb - Molecule ID A0477

geneBCL2L1, BCL2L, BCLX
nameApoptosis regulator Bcl-X
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
B2CL1_HUMANQ07817ENSG00000171552598Hs.516966600039

Functions and classifications

GOC:Bcl-2 family protein complex, C:cell junction, C:centrosome, C:cytosol, C:integral component of membrane, C:mitochondrial inner membrane, C:mitochondrial matrix, C:mitochondrial outer membrane, C:nuclear membrane, C:synaptic vesicle membrane, F:protein heterodimerization activity, F:protein homodimerization activity, P:apoptotic process in bone marrow, P:cell proliferation, P:cellular process regulating host cell cycle in response to virus, P:cellular response to alkaloid, P:cellular response to amino acid stimulus, P:cellular response to gamma radiation, P:cytokinesis, P:endocytosis, P:extrinsic apoptotic signaling pathway in absence of ligand, P:fertilization, P:germ cell development, P:growth, P:hepatocyte apoptotic process, P:in utero embryonic development, P:innate immune response, P:intrinsic apoptotic signaling pathway, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:male gonad development, P:mitotic cell cycle checkpoint, P:negative regulation of anoikis, P:negative regulation of autophagy, P:negative regulation of establishment of protein localization to plasma membrane, P:negative regulation of execution phase of apoptosis, P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:negative regulation of intrinsic apoptotic signaling pathway, P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, P:negative regulation of neuron apoptotic process, P:negative regulation of release of cytochrome c from mitochondria, P:neuron apoptotic process, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:ovarian follicle development, P:positive regulation of apoptotic process, P:positive regulation of cell proliferation, P:positive regulation of intrinsic apoptotic signaling pathway, P:regulation of mitochondrial membrane permeability, P:regulation of mitochondrial membrane potential, P:release of cytochrome c from mitochondria, P:response to cycloheximide, P:response to cytokine, P:spermatogenesis, P:suppression by virus of host apoptotic process, C:mitochondrial membrane, P:regulation of apoptotic process, C:integral to membrane, P:mitotic cell cycle G2/M transition checkpoint, P:negative regulation of apoptotic process, P:response to cytokine stimulus, P:spermatogenesis
UniProt3D-structure, Alternative splicing, Apoptosis, Cell junction, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endocytosis, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Nucleus, Phosphoprotein, Reference proteome, Synapse, Transmembrane, Transmembrane helix
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.270.0113661RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.130.000568RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.150.000175RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.240.000248RNA microarray19698090
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.540.012445RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium