CKDdb-logoCKDdb - Molecule ID A0476

geneBAD, BBC6, BCL2L8
nameBcl2-antagonist of cell death
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BAD_HUMANQ92934ENSG00000002330572Hs.370254603167

Functions and classifications

GOC:cytosol, C:mitochondrial outer membrane, F:cysteine-type endopeptidase activator activity involved in apoptotic process, F:phospholipid binding, P:ADP metabolic process, P:ATP metabolic process, P:cellular process regulating host cell cycle in response to virus, P:cellular response to chromate, P:cellular response to hypoxia, P:cellular response to lipid, P:cellular response to mechanical stimulus, P:cellular response to nicotine, P:cytokine-mediated signaling pathway, P:epidermal growth factor receptor signaling pathway, P:extrinsic apoptotic signaling pathway, P:extrinsic apoptotic signaling pathway in absence of ligand, P:extrinsic apoptotic signaling pathway via death domain receptors, P:Fc-epsilon receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:glucose catabolic process, P:glucose homeostasis, P:innate immune response, P:intrinsic apoptotic signaling pathway, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:neurotrophin TRK receptor signaling pathway, P:phosphatidylinositol-mediated signaling, P:pore complex assembly, P:positive regulation of apoptotic process, P:positive regulation of apoptotic process by virus, P:positive regulation of autophagy, P:positive regulation of B cell differentiation, P:positive regulation of epithelial cell proliferation, P:positive regulation of glucokinase activity, P:positive regulation of insulin secretion, P:positive regulation of insulin secretion involved in cellular response to glucose stimulus, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of mitochondrial membrane potential, P:positive regulation of neuron death, P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, P:positive regulation of proteolysis, P:positive regulation of release of cytochrome c from mitochondria, P:positive regulation of T cell differentiation, P:positive regulation of type B pancreatic cell development, P:regulation of mitochondrial membrane permeability, P:release of cytochrome c from mitochondria, P:response to amino acid, P:response to calcium ion, P:response to drug, P:response to estradiol, P:response to ethanol, P:response to glucocorticoid, P:response to glucose, P:response to hydrogen peroxide, P:response to oleic acid, P:response to progesterone, P:response to testosterone, P:suppression by virus of host apoptotic process, P:type B pancreatic cell proliferation, C:mitochondrion, P:response to hypoxia, P:induction of apoptosis, P:nerve growth factor receptor signaling pathway, P:activation of cysteine-type endopeptidase activity involved in apoptotic process
UniProt3D-structure, Acetylation, Apoptosis, Complete proteome, Cytoplasm, Membrane, Methylation, Mitochondrion, Mitochondrion outer membrane, Phosphoprotein, Polymorphism, Reference proteome
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.410.00819RNA microarray19698090
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.30.000865RNA microarray23291264

Compile date 08-10-2018© iMODE-CKD consortium