CKDdb-logoCKDdb - Molecule ID A0466

geneAKT2
nameRAC-beta serine/threonine protein kinase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AKT2_HUMANP31751ENSG00000105221208Hs.631535125853, 164731, 240900

Functions and classifications

GOC:cell cortex, C:cytosol, C:nucleus, C:ruffle membrane, F:ATP binding, F:protein serine/threonine kinase activity, P:activation of Ral GTPase activity, P:apoptotic process, P:carbohydrate transport, P:fat cell differentiation, P:glucose metabolic process, P:glycogen biosynthetic process, P:insulin receptor signaling pathway, P:intracellular protein transmembrane transport, P:mammary gland epithelial cell differentiation, P:negative regulation of plasma membrane long-chain fatty acid transport, P:peripheral nervous system myelin maintenance, P:positive regulation of cell motility, P:positive regulation of fatty acid beta-oxidation, P:positive regulation of glucose import, P:positive regulation of glucose import in response to insulin stimulus, P:positive regulation of glycogen biosynthetic process, P:positive regulation of protein phosphorylation, P:positive regulation of protein targeting to membrane, P:positive regulation of vesicle fusion, P:protein localization to plasma membrane, P:regulation of cell cycle arrest, P:regulation of cell migration, P:regulation of translation, F:protein kinase activity, C:insulin-responsive compartment, C:lamellipodium, C:mitochondrion, C:nucleoplasm, F:phospholipid binding, P:negative regulation of apoptotic process, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:negative regulation of RNA splicing, P:positive regulation of cell migration, P:positive regulation of nitric oxide biosynthetic process, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of positive chemotaxis, P:positive regulation of signal transduction, P:positive regulation of sodium ion transport, P:positive regulation of transcription from RNA polymerase II promoter, P:protein kinase B signaling cascade, P:regulation of JNK cascade, P:response to muscle activity, P:response to osmotic stress, C:plasma membrane, P:cellular response to insulin stimulus, F:transferase activity, transferring phosphorus-containing groups, P:metabolic process
UniProt3D-structure, Apoptosis, ATP-binding, Carbohydrate metabolism, Cell membrane, Complete proteome, Cytoplasm, Developmental protein, Diabetes mellitus, Disease mutation, Disulfide bond, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, Serine/threonine-protein kinase, Sugar transport, Transferase, Translation regulation, Transport, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.470.0425RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.490.002RNA microarray19698090
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.870.014631RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium