CKDdb-logoCKDdb - Molecule ID A0460

geneAbl2, Arg
nameAbelson tyrosine-protein kinase 2
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABL2_MOUSEQ4JIM5ENSMUSG0000002659611352Mm.329515164690

Functions and classifications

GOC:actin cytoskeleton, C:cytoplasmic membrane-bounded vesicle, F:ATP binding, F:magnesium ion binding, F:manganese ion binding, F:non-membrane spanning protein tyrosine kinase activity, F:protein tyrosine kinase activity, P:actin cytoskeleton organization, P:actin filament bundle assembly, P:actin filament organization, P:cell adhesion, P:peptidyl-tyrosine phosphorylation, P:protein phosphorylation, C:actin cytoskeleton, C:cytoplasmic membrane-bounded vesicle, F:ATP binding, F:magnesium ion binding, F:manganese ion binding, F:non-membrane spanning protein tyrosine kinase activity, P:actin filament bundle assembly, P:actin filament organization, P:cellular response to retinoic acid, P:positive regulation of neuron projection development, P:positive regulation of oxidoreductase activity, C:actin cytoskeleton, C:cytoplasmic membrane-bounded vesicle, F:ATP binding, F:non-membrane spanning protein tyrosine kinase activity, P:actin filament bundle assembly, P:actin filament organization, C:actin cytoskeleton, C:cytoplasmic membrane-bounded vesicle, P:actin filament bundle assembly, P:actin filament organization, C:actin cytoskeleton, C:cytoplasmic membrane-bounded vesicle, F:ATP binding, F:non-membrane spanning protein tyrosine kinase activity, P:actin filament bundle assembly, P:actin filament organization, C:actin cytoskeleton, C:cytoplasmic membrane-bounded vesicle, F:ATP binding, F:magnesium ion binding, F:manganese ion binding, F:protein tyrosine kinase activity, P:actin filament bundle assembly, P:actin filament organization, P:cellular response to retinoic acid, P:positive regulation of neuron projection development, P:positive regulation of oxidoreductase activity
UniProtATP-binding, Cell adhesion, Complete proteome, Cytoplasm, Cytoskeleton, Kinase, Lipoprotein, Magnesium, Manganese, Metal-binding, Myristate, Nucleotide-binding, Phosphoprotein, Reference proteome, SH2 domain, SH3 domain, Transferase, Tyrosine-protein kinase, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease) 3.610.0206523RNA microarray  23935909
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI) 2.090.00000657RNA microarray  24569379

Compile date 08-30-2016© iMODE-CKD consortium