CKDdb-logoCKDdb - Molecule ID A0429

geneAco2
nameAconitate hydratase
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACON_RATQ9ER34ENSRNOG0000002412879250Rn.43737100850, 614559

Functions and classifications

GOC:mitochondrion, C:nucleus, F:3 iron, 4 sulfur cluster binding, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron ion binding, F:protein binding, P:citrate metabolic process, P:isocitrate metabolic process, P:tricarboxylic acid cycle, F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, P:tricarboxylic acid cycle
UniProt4Fe-4S, Acetylation, Complete proteome, Direct protein sequencing, Iron, Iron-sulfur, Isopeptide bond, Lyase, Metal-binding, Mitochondrion, Phosphoprotein, Pyrrolidone carboxylic acid, Reference proteome, Transit peptide, Tricarboxylic acid cycle, Ubl conjugation,
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp18850734Canis lupus familiaris kidneydistal renal tubular cellskidney_calculi (Calcium oxalate monohydrate in vitro model) 2.170.01Q-TOF MS/MS  18850734
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.390.02cDNA microarray  19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.420.01cDNA microarray  19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.460.01cDNA microarray  19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.460cDNA microarray  19099603
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy) down MS/MS, LTQ LX linear ion trap  20093355
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model) 1.15< 0.05LC-MS/MS  20940332
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 1.840.003MALDI-TOF/TOF  21544065
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy) 0.353.00E-03Nano RP-LC, MALDI-TOF  22061828
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity) 0.430.00568RNA microarray  23291264
Exp24761003cRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy) 0.74< 0.05LC-MS/MS  24761003
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 4.90.01492RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium