CKDdb-logoCKDdb - Molecule ID A0419

geneGSN
nameGelsolin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
GELS_HUMANP06396ENSG000001481802934Hs.522373105120, 137350

Functions and classifications

GOC:actin cytoskeleton, C:cytosol, C:extracellular space, C:extracellular vesicular exosome, C:lamellipodium, C:perinuclear region of cytoplasm, C:protein complex, C:ruffle, F:calcium ion binding, P:actin filament polymerization, P:actin filament severing, P:aging, P:barbed-end actin filament capping, P:cellular component disassembly involved in execution phase of apoptosis, P:cellular response to cadmium ion, P:cilium morphogenesis, P:oligodendrocyte development, P:phosphatidylinositol-mediated signaling, P:regulation of cell adhesion, P:response to ethanol, P:response to folic acid, P:tissue regeneration, P:vesicle-mediated transport, P:actin polymerization or depolymerization, P:apoptotic process
UniProt3D-structure, Actin capping, Actin-binding, Alternative initiation, Alternative splicing, Amyloid, Amyloidosis, Calcium, Cilium biogenesis/degradation, Complete proteome, Corneal dystrophy, Cytoplasm, Cytoskeleton, Direct protein sequencing, Disease mutation, Disulfide bond, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.4< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.69< 0.05cDNA microarray17003339
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes)up< 0.05MALDI-TOF-MS17609286
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0 LC-MS/MS18440303
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.240.02cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.130.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.260.000948RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.00000529RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20134395Homo sapiens9urinewholeFibrosis (Interstitial fibrosis and tubular atrophy)4.080.045MALDI-TOF-MS, LTQ linear ion trap, capLC-ESI-ITMS/MS20134395
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)1.56< 0.05LC-MS/MS20639044
Exp20639044bHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)4.71< 0.05LC-MS/MS20639044
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)0.54< 0.05LC-MS/MS20940332
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.162.00E-04Nano RP-LC, MALDI-TOF22061828
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)0.890.0098QSTAR Elite LC-MS/MS22172726
Exp23464927Homo sapiens10urine Fabry (12 months of ERT)1.47<0.05QTOF MS/MS23464927
Exp23671862aMus musculus8heartsectionDiabetes (Diabetic Cardiomyopathy)0.41< 0.05micro-liquid chromatography system + LTQ Velos ion trap mass spectrometer23671862
Exp23671862bMus musculus8heartsectionDiabetes (Diabetic Cardiomyopathy)2.33< 0.05micro-liquid chromatography system + LTQ Velos ion trap mass spectrometer23671862
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)1000 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)1000 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)13 1DE, MALDI24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)8.4 1DE, MALDI24096133
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.610.022108183LC-MS/MS24172336
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)0.340.02LC-MS/MS24726496
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)0.350.02LC-MS/MS24726496
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)2.34.40E-04LC-MS25150443

Compile date 08-10-2018© iMODE-CKD consortium