CKDdb-logoCKDdb - Molecule ID A0418

geneCAPZB
nameCapping protein (actin filament) muscle Z-line
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAPZB_HUMANP47756ENSG00000077549832Hs.432760601572

Functions and classifications

GOC:acrosomal vesicle, C:cortical cytoskeleton, C:cytosol, C:F-actin capping protein complex, C:intercalated disc, C:lamellipodium, C:membrane, C:WASH complex, C:Z disc, F:actin binding, P:actin cytoskeleton organization, P:barbed-end actin filament capping, P:blood coagulation, P:cellular component movement, P:cytoskeleton organization, P:lamellipodium assembly, P:muscle fiber development, P:negative regulation of microtubule polymerization, P:neuron projection development, P:regulation of cell morphogenesis, P:regulation of protein kinase C signaling, P:actin filament capping, C:cytoplasm
UniProtAcetylation, Actin capping, Actin-binding, Alternative splicing, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Reference proteome, Phosphoprotein
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19688724Mus musculus kidneypodocytesHigh_glucose_induced (High glucose in vitro model)0.2< 0.05MALDI-TOF-MS19688724
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.0188RNA microarray19698090
Exp20485333Homo sapiens20bloodwholeGlomerulonephritis (IgA nephropathy)0.340.000923RNA microarray20485333
Exp22159597Rattus norvegicus30kidneyglomeruliGlomerulonephritis (mesangial proliferative glomerulonephritis) 0.005LC-MS22159597
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)2.290.030884RNA microarray23935909

Compile date 08-10-2018© iMODE-CKD consortium