CKDdb-logoCKDdb - Molecule ID A0415

geneATP6V0A2, TJ6
nameVacuolar proton translocating ATPase 116 kDa subunit a isoform 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
VPP2_HUMANQ9Y487ENSG0000018534423545Hs.25786219200, 278250, 611716

Functions and classifications

GOC:acrosomal vesicle, C:endosome membrane, C:integral component of membrane, C:lysosomal membrane, C:phagocytic vesicle membrane, C:plasma membrane, C:vacuolar proton-transporting V-type ATPase, V0 domain, F:hydrogen ion transmembrane transporter activity, P:ATP hydrolysis coupled proton transport, P:cellular iron ion homeostasis, P:immune response, P:insulin receptor signaling pathway, P:interaction with host, P:phagosome maturation, P:transferrin transport, P:transmembrane transport, C:proton-transporting V-type ATPase, V0 domain, P:ATP hydrolysis coupled proton transport, C:proton-transporting V-type ATPase, V0 domain, C:cytoplasm, C:integral to membrane, C:proton-transporting two-sector ATPase complex, proton-transporting domain, C:proton-transporting two-sector ATPase complex, proton-transporting domain
UniProtCell membrane, Complete proteome, Endosome, Hydrogen ion transport, Ion transport, Membrane, Phosphoprotein, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.220.0025RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.00658RNA microarray19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.020.045324529LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium