CKDdb-logoCKDdb - Molecule ID A0414

geneATP6V0A1, ATP6N1, ATP6N1A
nameVacuolar proton translocating ATPase 116 kDa subunit a isoform 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
VPP1_HUMANQ93050ENSG00000033627535Hs.463074192130

Functions and classifications

GOC:endosome membrane, C:Golgi apparatus, C:integral component of membrane, C:melanosome, C:nucleus, C:phagocytic vesicle membrane, C:plasma membrane, C:vacuolar proton-transporting V-type ATPase, V0 domain, F:hydrogen ion transmembrane transporter activity, P:ATP hydrolysis coupled proton transport, P:cellular iron ion homeostasis, P:insulin receptor signaling pathway, P:interaction with host, P:phagosome maturation, P:transferrin transport, P:transmembrane transport, C:vacuolar proton-transporting V-type ATPase, V0 domain, P:ATP hydrolysis coupled proton transport, C:proton-transporting V-type ATPase, V0 domain, C:Golgi apparatus, C:integral to membrane, C:proton-transporting two-sector ATPase complex, proton-transporting domain, C:cytoplasm, C:proton-transporting V-type ATPase, V0 domain
UniProtAlternative splicing, Complete proteome, Cytoplasmic vesicle, Hydrogen ion transport, Ion transport, Membrane, Phosphoprotein, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0000137RNA microarray19698090
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)0.310.018155437LC-MS/MS24316357

Compile date 08-10-2018© iMODE-CKD consortium