CKDdb-logoCKDdb - Molecule ID A0411

geneATP6C, ATP6V0C, ATP6L
nameVacuolar ATP synthase 16 kDa proteolipid subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
VATL_HUMANP27449ENSP00000329757527Hs.389107108745

Functions and classifications

GOC:endosome membrane, C:integral component of membrane, C:lysosomal membrane, C:phagocytic vesicle membrane, C:proton-transporting V-type ATPase, V0 domain, F:proton-transporting ATP synthase activity, rotational mechanism, F:proton-transporting ATPase activity, rotational mechanism, P:ATP hydrolysis coupled proton transport, P:cellular iron ion homeostasis, P:insulin receptor signaling pathway, P:interaction with host, P:phagosome maturation, P:transferrin transport, P:viral process, C:integral component of membrane, F:hydrogen ion transmembrane transporter activity, P:ATP hydrolysis coupled proton transport, C:integral to membrane, C:vacuolar membrane, F:hydrogen ion transporting ATP synthase activity, rotational mechanism, P:virus-host interaction, C:integral to membrane
UniProtComplete proteome, Host-virus interaction, Hydrogen ion transport, Ion transport, Membrane, Reference proteome, Transmembrane, Transmembrane helix, Transport, Ubl conjugation, Vacuole
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp24927646aMus musculus16kidneyDiabetes (diabetic nephropathy treated with Phlorizin)0.92< 0.05LC-MS/MS24927646
Exp24927646bMus musculus16kidneyDiabetes (diabetic nephropathy)0.47< 0.05LC-MS/MS24927646

Compile date 08-10-2018© iMODE-CKD consortium