CKDdb-logoCKDdb - Molecule ID A0400

geneATP6V1B2, ATP6B2, VPP3
nameVacuolar ATP synthase subunit B
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
VATB2_HUMANP21281ENSG00000147416526Hs.295917606939

Functions and classifications

GOC:cytosol, C:endomembrane system, C:Golgi apparatus, C:integral component of membrane, C:lysosomal membrane, C:melanosome, C:microvillus, C:plasma membrane, C:proton-transporting V-type ATPase, V1 domain, F:ATP binding, F:proton-transporting ATPase activity, rotational mechanism, P:ATP hydrolysis coupled proton transport, P:cellular iron ion homeostasis, P:insulin receptor signaling pathway, P:interaction with host, P:phagosome maturation, P:transferrin transport, C:proton-transporting two-sector ATPase complex, catalytic domain, F:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, P:metabolic process, P:ATP metabolic process, P:proton transport, C:proton-transporting two-sector ATPase complex, catalytic domain, C:integral to membrane, P:ATP hydrolysis coupled proton transport
UniProtComplete proteome, Hydrogen ion transport, Hydrolase, Ion transport, Membrane, Reference proteome, Transport, Phosphoprotein
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes)up< 0.05MALDI-TOF-MS17609286
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.410.000000115RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.160.014MALDI-TOF/TOF21544065
Exp22159597Rattus norvegicus30kidneyglomeruliGlomerulonephritis (mesangial proliferative glomerulonephritis) 0.00059LC-MS22159597
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.21 nLC-ESI-UHR-QToF-MS/MS23344851

Compile date 08-10-2018© iMODE-CKD consortium