CKDdb-logoCKDdb - Molecule ID A0377

geneAtp5a1
nameATP synthase subunit alpha, mitochondrial
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATPA_MOUSEQ03265ENSMUSG0000002542811946Mm.276137164360, 615228

Functions and classifications

GOC:COP9 signalosome, C:mitochondrial inner membrane, C:mitochondrial proton-transporting ATP synthase complex, C:mitochondrion, C:plasma membrane, C:proton-transporting ATP synthase complex, catalytic core F(1), F:ATP binding, F:proton-transporting ATP synthase activity, rotational mechanism, F:proton-transporting ATPase activity, rotational mechanism, P:ATP hydrolysis coupled proton transport, P:ATP synthesis coupled proton transport, P:lipid metabolic process, P:negative regulation of endothelial cell proliferation, C:mitochondrial proton-transporting ATP synthase complex, catalytic core F(1), C:signalosome, F:ADP binding, F:eukaryotic cell surface binding, F:hydrogen ion transporting ATP synthase activity, rotational mechanism, P:ADP biosynthetic process, P:embryo development, P:hydrogen ion transmembrane transport
UniProtAcetylation, ATP synthesis, ATP-binding, Cell membrane, CF(1), Complete proteome, Direct protein sequencing, Hydrogen ion transport, Ion transport, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleotide-binding, Phosphoprotein, Pyrrolidone carboxylic acid, Reference proteome, Transit peptide, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18850734Canis lupus familiaris kidneydistal renal tubular cellskidney_calculi (Calcium oxalate monohydrate in vitro model)0.50.029Q-TOF MS/MS18850734
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.40.01cDNA microarray19099603
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355

Compile date 08-10-2018© iMODE-CKD consortium