CKDdb-logoCKDdb - Molecule ID A0373

geneADAM22, MDC2
nameADAM 22 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA22_HUMANQ9P0K1ENSG0000000827753616Hs.256398603709

Functions and classifications

GOC:integral component of membrane, F:integrin binding, F:metalloendopeptidase activity, F:zinc ion binding, P:adult locomotory behavior, P:cell adhesion, P:central nervous system development, P:myelination in peripheral nervous system, P:negative regulation of cell adhesion, P:proteolysis, P:integrin-mediated signaling pathway, C:extracellular region, C:integral to membrane, F:metal ion binding
UniProt3D-structure, Alternative splicing, Cell adhesion, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, EGF-like domain, Glycoprotein, Membrane, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Signal, Transmembrane, Transmembrane helix, Integrin, Secreted, Hydrolase, Metal-binding, Metalloprotease, Protease
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)5.31< 0.05cDNA microarrays17183245
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.220.00192RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.00813RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.390.0157RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.430.0156RNA microarray19698090
Exp25449168Rattus norvegicus pancreasbeta-cells (INS-1 cell line)Diabetes (pancreatic beta-cell function)3.4 LC-MS/MS25449168
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.313.10E-03RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.361.17E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.451.46E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium