CKDdb-logoCKDdb - Molecule ID A0343

geneAtp1a4
nameSodium/potassium-transporting ATPase subunit alpha-4
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AT1A4_RATQ64541ENSRNOG0000003237829132Rn.224462607321

Functions and classifications

GOC:sodium:potassium-exchanging ATPase complex, F:ATP binding, F:metal ion binding, F:sodium:potassium-exchanging ATPase activity, P:ATP biosynthetic process, P:fertilization, P:potassium ion transport, P:regulation of cellular pH, P:regulation of membrane potential, P:sodium ion transmembrane transport, P:sodium ion transport, P:sperm motility, P:spermatogenesis, C:integral component of membrane, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, F:monovalent inorganic cation transmembrane transporter activity
UniProtATP-binding, Cell membrane, Complete proteome, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Potassium, Potassium transport, Reference proteome, Sodium, Sodium transport, Sodium/potassium transport, Transmembrane, Transm
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.07< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)0.12< 0.05RNA-seq23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.372.57E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)12.670.006399RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium