CKDdb-logoCKDdb - Molecule ID A0342

geneATP1A3
nameSodium/potassium-transporting ATPase alpha-3 chain
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AT1A3_HUMANP13637ENSG00000105409478Hs.515427128235, 182350, 614820

Functions and classifications

GOC:axon, C:dendritic spine head, C:dendritic spine neck, C:endoplasmic reticulum, C:Golgi apparatus, C:myelin sheath, C:nucleus, C:sodium:potassium-exchanging ATPase complex, C:synapse, F:ATP binding, F:metal ion binding, F:sodium:potassium-exchanging ATPase activity, P:adult locomotory behavior, P:ATP biosynthetic process, P:ionotropic glutamate receptor signaling pathway, P:memory, P:response to drug, P:visual learning, C:integral component of membrane, F:cation-transporting ATPase activity, P:ATP catabolic process, P:ion transmembrane transport, F:monovalent inorganic cation transmembrane transporter activity, C:cytoplasm, P:potassium ion transport, P:sodium ion transport, F:nucleotide binding, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:cation transport, P:ATP biosynthetic process, C:membrane, C:axon, P:visual learning
UniProtAlternative splicing, ATP-binding, Cell membrane, Complete proteome, Disease mutation, Dystonia, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Parkinsonism, Phosphoprotein, Potassium, Potassium transport, Reference proteome, Sodium, Sodium transport, Sodium/potassium transport, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.240.00104RNA microarray19698090
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.480cDNA microarray21411733
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.420.0052RNA microarray23291264
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)2.841.50E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)9.650.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium