CKDdb-logoCKDdb - Molecule ID A0341

geneATP1A2
nameSodium/potassium-transporting ATPase alpha-2 chain precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AT1A2_HUMANP50993ENSG00000018625477Hs.34114104290, 182340, 602481

Functions and classifications

GOC:caveola, C:cytoplasm, C:dendritic spine, C:endosome, C:sodium:potassium-exchanging ATPase complex, C:synapse, C:T-tubule, F:ATP binding, F:metal ion binding, F:sodium:potassium-exchanging ATPase activity, P:adult locomotory behavior, P:ATP biosynthetic process, P:ATP hydrolysis coupled proton transport, P:cellular response to mechanical stimulus, P:locomotion, P:negative regulation of cytosolic calcium ion concentration, P:negative regulation of heart contraction, P:negative regulation of striated muscle contraction, P:neurotransmitter uptake, P:regulation of blood pressure, P:regulation of cardiac muscle cell contraction, P:regulation of respiratory gaseous exchange by neurological system process, P:regulation of smooth muscle contraction, P:regulation of striated muscle contraction, P:regulation of the force of heart contraction, P:regulation of vasoconstriction, P:response to nicotine, P:visual learning, C:integral component of membrane, F:cation-transporting ATPase activity, F:monovalent inorganic cation transmembrane transporter activity, P:ATP catabolic process, P:ion transmembrane transport, P:potassium ion transmembrane transport, P:sodium ion transmembrane transport, C:sarcolemma, P:reduction of cytosolic calcium ion concentration, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:ATP biosynthetic process, C:membrane, P:cation transport
UniProtATP-binding, Cell membrane, Complete proteome, Disease mutation, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Potassium, Potassium transport, Reference proteome, Sodium, Sodium transport, Sodium/potassium transport, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.460.0197787RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.0144RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)4.413.23E-06RNA microarray20019191

Compile date 08-10-2018© iMODE-CKD consortium