CKDdb-logoCKDdb - Molecule ID A0340

geneATP1A1
nameSodium/potassium-transporting ATPase alpha-1 chain precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AT1A1_HUMANP05023ENSG00000163399476Hs.371889182310

Functions and classifications

GOC:basolateral plasma membrane, C:caveola, C:endoplasmic reticulum, C:endosome, C:Golgi apparatus, C:melanosome, C:sodium:potassium-exchanging ATPase complex, C:T-tubule, F:ADP binding, F:ATP binding, F:chaperone binding, F:potassium ion binding, F:sodium ion binding, F:sodium:potassium-exchanging ATPase activity, P:ATP biosynthetic process, P:cellular response to mechanical stimulus, P:membrane hyperpolarization, P:negative regulation of glucocorticoid biosynthetic process, P:negative regulation of heart contraction, P:positive regulation of heart contraction, P:positive regulation of striated muscle contraction, P:potassium ion import, P:regulation of blood pressure, P:regulation of cardiac muscle cell contraction, P:regulation of sodium ion transport, P:regulation of the force of heart contraction, P:response to drug, C:integral component of membrane, F:cation-transporting ATPase activity, F:metal ion binding, F:monovalent inorganic cation transmembrane transporter activity, P:ATP catabolic process, P:ion transmembrane transport, P:sodium ion transmembrane transport, C:sarcolemma, F:4-nitrophenylphosphatase activity, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:ATP biosynthetic process, P:cation transport, C:membrane
UniProtAlternative splicing, ATP-binding, Cell membrane, Complete proteome, Direct protein sequencing, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Potassium, Potassium transport, Reference proteome, Sodium, Sodium transport, Sodium/potassium transport, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.470.02cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.30.000000831RNA microarray19698090
Exp22972526Rattus norvegicus kidneycortexDiabetes (streptozotocin-induced diabetic) < 0.05LC-MS/MS22972526
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)2.21 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)1.280.001101429LC-MS/MS24316357
Exp24761003dRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.68< 0.05LC-MS/MS24761003
Exp24761003eRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.94< 0.05LC-MS/MS24761003
Exp24761003fRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.75< 0.05LC-MS/MS24761003

Compile date 08-10-2018© iMODE-CKD consortium