CKDdb-logoCKDdb - Molecule ID A0317

geneCAPN1, CANPL1, PIG30
nameCalpain 1, large [catalytic] subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAN1_HUMANP07384ENSP00000279247823Hs.502842114220

Functions and classifications

GOC:cytoplasm, C:plasma membrane, F:calcium ion binding, F:calcium-dependent cysteine-type endopeptidase activity, P:positive regulation of cell proliferation, P:proteolysis, P:receptor catabolic process, C:intracellular, P:protein autoprocessing
UniProt3D-structure, Acetylation, Autocatalytic cleavage, Calcium, Cell membrane, Complete proteome, Cytoplasm, Hydrolase, Membrane, Metal-binding, Polymorphism, Protease, Reference proteome, Repeat, Thiol protease
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.03< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.050.045324529LC-MS/MS24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.30.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium