CKDdb-logoCKDdb - Molecule ID A0254

geneAP2M1, CLAPM1
nameAP-2 complex subunit mu
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AP2M1_HUMANQ96CW1ENSP000002928071173Hs.518460601024

Functions and classifications

GOC:clathrin adaptor complex, C:clathrin-coated endocytic vesicle membrane, C:coated pit, C:cytosol, C:lysosomal membrane, C:mitochondrion, C:plasma membrane, F:lipid binding, F:transporter activity, P:antigen processing and presentation of exogenous peptide antigen via MHC class II, P:axon guidance, P:endocytosis, P:epidermal growth factor receptor signaling pathway, P:intracellular protein transport, P:negative regulation of epidermal growth factor receptor signaling pathway, P:neurotrophin TRK receptor signaling pathway, P:regulation of defense response to virus by virus, P:synaptic transmission, P:viral process, P:vesicle-mediated transport, P:transport, C:clathrin coat of coated pit, P:cellular membrane organization, P:nerve growth factor receptor signaling pathway, P:viral reproduction
UniProt3D-structure, Alternative splicing, Cell membrane, Coated pit, Complete proteome, Endocytosis, Lipid-binding, Membrane, Phosphoprotein, Protein transport, Reference proteome, Transport
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)4.79< 0.05LC-MS/MS19845401
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.95< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.620.013755561LC-MS/MS24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.640.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium