CKDdb-logoCKDdb - Molecule ID A0252

geneAP2A2, ADTAB, CLAPA2
nameAdapter-related protein complex 2 alpha 2 subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AP2A2_HUMANO94973ENSG00000183020161Hs.19121607242

Functions and classifications

GOC:AP-2 adaptor complex, C:cytosol, F:lipid binding, F:protein transporter activity, P:antigen processing and presentation of exogenous peptide antigen via MHC class II, P:axon guidance, P:endocytosis, P:epidermal growth factor receptor signaling pathway, P:intracellular protein transport, P:negative regulation of epidermal growth factor receptor signaling pathway, P:neurotrophin TRK receptor signaling pathway, P:regulation of defense response to virus by virus, P:synaptic transmission, P:viral process, C:membrane coat, P:vesicle-mediated transport, C:clathrin adaptor complex, P:nerve growth factor receptor signaling pathway, P:viral reproduction, C:plasma membrane
UniProtAlternative splicing, Cell membrane, Coated pit, Complete proteome, Endocytosis, Lipid-binding, Membrane, Protein transport, Reference proteome, Transport, Phosphoprotein
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0212RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.37< 0.05RNA microarray21752957
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)0.320.001903889LC-MS/MS24316357
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)3.90.010399RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium